Cell Biology is the most taught basic science course in medical school as it is one of the most rapidly
developing subjects in science. Cell biology overlaps with molecular biology, histology, pathology, cancer
biology, neuroscience, and many other major related disciplines. Having an up-to-date Cell Biology
textbook that covers many functional aspects is essential for medical students to cross the bridge
between basic sciences and clinical courses.
This textbook was edited and modified fro
內容簡介：
Cell Biology is the most taught basic science course in medical school as it is one of the most rapidly developing subjects in science. Cell biology overlaps with molecular biology, histology, pathology, cancer biology, neuroscience, and many other major related disciplines. Having an up-to-date Cell Biology textbook that covers many functional aspects is essential for medical students to cross the bridge between basic sciences and clinical courses. This textbook was edited and modified from Medical Cell Biology, Steven R. Goodman ed., Elsevier, 2008. The first several chapters serve as comprehensive introductions into organelle structure, functions and gene expression. The second half of this book details many topics in medical science, including cell signaling pathways, cell cycle, programmed cell death, and cancer. New technologies such as atomic force microscopy, proteomics, and gene therapy are also covered.
目錄：
Chapter 1 Tools of the Cell Biologist............................1
MICROSCOPY： ONE OF THE EARLIEST TOOLS
OF THE CELL BIOLOGIST...................................... 1
MORE TOOLS OF CELL BIOLOGY......................... 11
SUMMARY...................................................................16
SUGGESTED READINGS........................................... 16
Chapter 2 Cell Membranes........................................... 17
THE MOLECULAR STRUCTURE OF CELL
MEMBRANE............................................................ 19
MEMBRANE TRANSPORT OF SMALL
MOLECULES........................................................... 27
SUMMARY................................................................... 31
SUGGESTED READINGS........................................... 32
Chapter 3 Cytoskeleton.................................................. 33
MICROFILAMENTS.................................................... 33
INTERMEDIATE FILAMENTS................................. 40
MICROTUBULES......................................................... 43
SUMMARY................................................................... 48
SUGGESTED READINGS........................................... 48
Chapter 4 Organelle Structure and Function......... 49
THE NUCLEUS............................................................ 50
ENDOPLASMIC RETICULUM................................. 51
THE GOLGI COMPLEX.............................................. 66
ENDOCYTOSIS, ENDOSOMES, AND
LYSOSOMES............................................................ 73
MITOCHONDRIA....................................................... 77
PEROXISOMES............................................................ 87
SUMMARY................................................................... 88
SUGGESTED READINGS........................................... 89
Chapter 5 Cell Nucleus and Gene Expression......... 90
CELL NUCLEUS.......................................................... 90
DNA REPLICATION AND REPAIR ARE
CRITICAL NUCLEAR FUNCTIONS................... 98
GENE EXPRESSION.................................................. 104
SUMMARY................................................................. 116
SUGGESTED READINGS......................................... 116
Chapter 6 Cell Adhesion and the Extracellular
Matrix........................................................... 117
CELL ADHESION...................................................... 117
INTERCELLULAR JUNCTIONS............................. 119
CELL ADHESION HAS MANY IMPORTANT
ROLES IN TISSUE FUNCTION.......................... 128
CELL ADHESION RECEPTORS TRANSMIT
SIGNALS THAT REGULATE CELL
BEHAVIOR.........................................................................133
EXTRACELLULAR MATRIX................................... 134
SUMMARY.................................................................140
SUGGESTED READINGS......................................... 141
Chapter 7 Intercellular Signaling............................. 142
GENERAL MODES OF INTERCELLULAR
SIGNALING........................................................... 142
HORMONES............................................................... 144
XII 医学细胞生物学Meeddiiccaall Ceellll Biioollooggyy
GROWTH FACTORS................................................ 146
GASES： NITRIC OXIDE AND CARBON
MONOXIDE........................................................... 148
NEUROTRANSMITTERS......................................... 150
SUMMARY................................................................. 154
SUGGESTED READINGS......................................... 155
Chapter 8 Cell Signaling Events................................ 156
SIGNALING IS OFTEN MEDIATED BY CELLSURFACE
RECEPTORS....................................... 156
RECEPTOR TYROSINE KINASES AND RASDEPENDENT
SIGNAL TRANSDUCTION...... 157
SIGNALING BY CATALYTIC RECEPTORS
SERINE-THREONINE KINASES....................... 160
SIGNALING BY NONKINASE RECEPTORS....... 163
SIGNALING BY G-PROTEIN-COUPLED
RECEPTORS INVOLVES CLEAVAGE
OF GUANOSINE TRIPHOSPHATE TO
GUANOSINE DIPHOSPHATE.......................... 166
SIGNALING BY STEROID HORMONE
RECEPTORS REQUIRES LIGAND
INTERACTION WITHIN THE
CYTOPLASM OR NUCLEUS............................. 167
OTHER SIGNALING PATHWAYS
SIGNALING BY THE RENINANGIOTENSIN-
ALDOSTERONE SYSTEM....169
SIGNALING BY THE JAKSTAT PATHWAY..... 170
CALCIUMCALMODULIN SIGNAL
TRANSDUCTION................................................. 170
SIGNALING BY ION CHANNEL RECEPTORS..........171
SUMMARY................................................................. 172
SUGGESTED READINGS......................................... 172
Chapter 9 The Cell Cycle and Cancer..................... 173
CELL CYCLE： HISTORY.......................................... 173
THE CELL CYCLE IS REGULATED BY
CYCLIN AND RELATED PROTEINS............... 174
MITOSIS...................................................................... 176
MEIOSIS ..................................................................... 179
SENSORS RECOGNIZE SITES OF DNA
DAMAGE............................................................... 181
CELL-CYCLE ALTERATIONS AND CANCER ..........183
SUMMARY................................................................. 184
SUGGESTED READINGS......................................... 184
Chapter 10 Programmed Cell Death........................ 185
DISTINCT FORMS OF PROGRAMMED CELL
DEATH................................................................... 186
NEUROTROPHIN RECEPTORS............................. 189
CASPASES.................................................................. 191
SIGNALING PATHWAYS THAT PROMOTE
CELL SURVIVAL.................................................. 197
APOPTOSIS AND HUMAN DISEASE................... 200
SUMMARY................................................................. 201
SUGGESTED READINGS......................................... 201
內容試閱：
Cell Biology is the most taught basic science course in medical school as it is one of the most rapidly
developing subjects in science. Cell biology overlaps with molecular biology, histology, pathology, cancer
biology, neuroscience, and many other major related disciplines. Having an up-to-date Cell Biology
textbook that covers many functional aspects is essential for medical students to cross the bridge
between basic sciences and clinical courses.
This textbook was edited and modified from Medical Cell Biology, Steven R. Goodman ed., Elsevier,
2008. The first several chapters serve as comprehensive introductions into organelle structure, functions
and gene expression. The second half of this book details many topics in medical science, including cell
signaling pathways, cell cycle, programmed cell death, and cancer. New technologies such as atomic force microscopy, proteomics, and gene therapy are also covered.
Unlike many other general-purpose Cell Biology textbooks, this one is more medically oriented.We decided to keep all chapters in this edited version from the original book. In our edit, however, weremoved some graduate level material, as it would be either too sophisticated, or covered by other courseshistology, pathology, etc.. Students in China generally take Cell Biology in their freshmen year, so wewould like to give students a thoroughunderstanding of basic concepts.We felt that it was proper to also add several important topics. Much progress has been made in ourfield. Advances in single-cell technologies, induced pluripotent stem cells iPSC, epigenetic modifications,and revelations in next generation sequencing make it almost impossible to cover everything necessarywithout restructuring.We realized that a concise, tailor-made version of a widely used textbook can be an excellent toolfor medical students. However, creating such a resource required hard work and dedication from manyfaculty members. Most of the editors have been teaching cell biology for more than 10 years, and manyhave doctoral degrees on cell biology or related subjects.I hope this book will give you just a snapshot of the ever-changing world of life sciences. Best of luckand we hope you find your journey into cell biology filled with fascination and exhilaration.
LI Guang
Professor and Chairwoman
Department of Genetics
College of Basic Medical Sciences
Tianjin Medical University
July 22, 2018
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